منابع مشابه
Pin1 allows for differential Tau dephosphorylation in neuronal cells.
Neurofibrillary degeneration is likely to be related to abnormal Tau phosphorylation and aggregation. Among abnormal Tau phosphorylation sites, pThr231 is of particular interest since it is associated with early stages of Alzheimer's disease and is a binding site of Pin1, a peptidyl-prolyl cis/trans isomerase mainly involved in cell cycle regulation. In the present work, Pin1 level was found st...
متن کاملPin1-FADD interactions regulate Fas-mediated apoptosis in activated eosinophils.
Abnormally long-lived eosinophils (Eos) are the major inflammatory component of allergic responses in the lungs of active asthmatics. Eos recruited to the airways after allergen exposure produce and respond to IL-5 and GM-CSF, enhancing their survival. Prosurvival signaling activates Pin1, a peptidyl-prolyl cis-trans isomerase that binds to Bax and prevents its activation. How long-lived Eos, d...
متن کاملCortical neuronal apoptosis in CADASIL.
BACKGROUND AND PURPOSE Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by mutations of the NOTCH3 gene and is a model of pure vascular dementia. Cortical atrophy has been reported to be associated with cognitive decline in the disease, although the underlying mechanism is unknown. We postulated that apoptosis may be involved in this...
متن کاملTestosterone-induced neuronal apoptosis ELEVATED TESTOSTERONE INDUCES APOPTOSIS IN NEURONAL CELLS
ELEVATED TESTOSTERONE INDUCES APOPTOSIS IN NEURONAL CELLS Manuel Estrada*#, Anurag Varshney* and Barbara E. Ehrlich† Departments of Pharmacology and Cellular and Molecular Physiology, Yale University, New Haven, CT 06520, USA Running title: Testosterone-induced neuronal apoptosis * These authors contributed equally to this work and are listed alphabetically. †Corresponding author: Barbara E Ehr...
متن کاملThe neuronal apoptosis inhibitory protein suppresses neuronal differentiation and apoptosis in PC12 cells.
The human neuronal apoptosis inhibitory protein (NAIP) gene has been discovered as a candidate gene for spinal muscular atrophy, a genetic disorder characterized by motor neuron loss in the spinal cord. The telomeric NAIP gene on human chromosome 5 is deleted together with survival motor neurons (SMN) in many cases of the most severe forms of the disorder. NAIP, c-IAP1 (inhibitor of apoptosis-1...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2007
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.6.11.4316